Drugs & Vitamins

Daytrana Active Ingredients: Methylphenidate skin patches Representative Names: Daytrana, Methylphenidate transdermal system Available Product Images: What are Methylphenidate skin patches? What should I tell my health care provider before I take this medicine? How should this medicine be used? What if I miss a dose? What drug(s) may interact with Methylphenidate? What side effects may I notice from receiving Methylphenidate? What should I watch for while using Methylphenidate patches? Where can I keep my medicine? What are Methylphenidate skin patches? (Back to top) METHYLPHENIDATE TRANSDERMAL SYSTEM (Daytrana™) is a stimulant. It can improve attention span, concentration, and emotional control, and reduce restless or overactive behavior. This medicine treats attention-deficit hyperactivity disorder (ADHD). Federal law prohibits the transfer of methylphenidate to any person other than the person for whom it was prescribed. Do not share this medicine with anyone else. Generic Methylphenidate skin patches are not yet available. What should I tell my health care provider before I take this medicine? (Back to top) They need to know if you have any of these conditions: •regularly drink beverages containing alcohol •a history of drug abuse •glaucoma •heart failure or other heart disease; a heart structural abnormality •heart rhythm disturbance •history of recent heart attack •high blood pressure •liver disease •mental illness, including anxiety, bipolar disorder, depression, mania or schizophrenia •motion tics or a family history of motion tics (hard-to-control repeated twitching of any parts of your body) or verbal tics (hard-to-control repeating of sounds or words). •overactive thyroid •seizures (convulsions) or an abnormal EEG (electroencephalogram) •stroke •Tourette's syndrome or a family history of Tourette's syndrome (speech repetition or involuntary use of obscene language) •an unusual reaction to methylphenidate, other medicines, foods, dyes, or preservatives •pregnant or trying to get pregnant •breast-feeding How should this medicine be used? (Back to top) Methylphenidate skin patches are for external use only. Follow the directions on the prescription label. Use exactly as directed. Do not cut or trim the patch. Apply patch to the hip area. Apply to a clean, dry, area, free of irritations or cuts. Avoid the waistline, since clothing may cause the patch to rub off. After the patch is applied, record the time on the administration chart on each carton, and use the timetable to calculate what time the patch should be removed, or follow your prescriber's instructions for removal of the patch. Always wash your hands after handling a patch. Replace each patch at the same time each day (usually in the early morning), and remove it at the time you are told by your health care provider. When applying a new patch the next morning, use the opposite hip. Do not stop using except on your prescriber's advice. Do not use your medicine more often than directed. After you apply the patch correctly, bathing, swimming, or showering should not affect the patch or make it fall off. If a patch falls off, a new patch may be applied to a different area of the same hip. If a new patch is applied you should remove it at the same time the original patch was to be removed. Contact your pediatrician or health care professional regarding the use of this medicine in children less than 6 years of age. This patch is not normally used in young children. Special care may be needed. What if I miss a dose? (Back to top) If the patch falls off, you may replace it with another patch at a different site on the same hip. You must remove that patch also at the same time; do not wear it for a longer period of time. If you forget to apply a patch in the morning, you may do so later in the day, but you should remove the patch at the same time of day you normally remove the patch to reduce the possibility of side effects late in the day or at night. What drug(s) may interact with Methylphenidate? (Back to top) •amphetamine or dextroamphetamine •antacids •bretylium •caffeine •carbamazepine •clonidine •dexmethylphenidate •furazolidone •guarana •linezolid •lithium •mecasermin, recombinant, rh-IGF-1 •medicines for attention deficit hyperactivity disorder (ADHD) •medicines for colds, sinus, and breathing difficulties (for example, pseudoephedrine) •medicines for high blood pressure •medicines called MAO inhibitors- examples: phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®) •other medicines for mental depression or anxiety, such as the Selective Serotonin Reuptake Inhibitors (SSRIs) or the tricyclic antidepressants (TCAs), duloxetine, nefazodone, or venlafaxine •medicines to decrease appetite or cause weight loss •modafinil •pemoline •procarbazine •radiopaque contrast agents •seizure (convulsion) or epilepsy medicine, such as phenytoin, primidone or phenobarbital •warfarin •water pills (diuretics) Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines. What side effects may I notice from receiving Methylphenidate? (Back to top) Side effects that you should report to your prescriber or health care professional as soon as possible: •abnormal or extreme weight loss •anxiety or severe nervousness •blurred vision •bruising •changes in mood or behavior, including seeing or hearing things that are not really there or over-focused, staring-type behavior •chest pain, fast or irregular heartbeat (palpitations) •fever, or hot, dry skin •increased blood pressure •joint pain •skin rash, itching, irritation, swelling or redness at the site where you applied the patch •skin rash or peeling of your skin at any area; redness, blistering, peeling or loosening of the skin, including inside the mouth •uncontrollable head, mouth, neck, arm, or leg movements Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome): Less Common or Rare: •a sense of well being •dizziness or lightheadedness •stomachache or cramps More Common, especially in the first few weeks of treatment: •decreased appetite or loss of appetite •headache •mild stomach upset •nervousness, restlessness, or difficulty sleeping •minor weight loss What should I watch for while using Methylphenidate patches? (Back to top) Visit your prescriber or health care professional for regular checks on your progress. This prescription requires that you follow special procedures with your prescriber and pharmacy; you will need to have a new written prescription from your prescriber every time you need a refill. If you notice a rash, irritation, redness, itching or swelling around the site of your patch that does not go away after 1—2 days, contact your health care provider. You may have allergy or just irritation. Your health care provider can best determine if you should continue using methylphenidate. If you notice peeling of your skin, or blisters in your mouth, contact your health care provider immediately. If you have previously had an allergy to the methylphenidate patch, you may not be able to use the oral tablets. Tell your health care provider if you have ever had an allergy to methylphenidate. Methylphenidate may affect your concentration, or hide signs of tiredness. Until you know how this drug affects you, do not drive, ride a bicycle, use machinery, or do anything that needs mental alertness. If you are having trouble sleeping or have weight loss, and this continues to be a regular and bothersome side effect, contact your health care provider to discuss your options. Tell your prescriber or health care professional if this medicine loses its effects, or if you feel you need to take more than the prescribed amount. Do not change the dosage without advice from your prescriber or health care professional. Do not suddenly stop your medication without prescriber approval. Ask your prescriber or health care professional for advice. Decreased appetite is a common side effect when starting this medicine. Eating small, frequent meals or snacks can help. Talk to your prescriber if you continue to have poor eating habits. Height and weight growth of a child taking this medication will be monitored closely. If you are going to have surgery or other medical procedures, tell your health care professional that you are using methylphenidate patches. Where can I keep my medicine? (Back to top) Keep out of the reach of children and pets. Keep your patches in a container that small children cannot open. Do not store the patches out of the original pouch that they came in. Store between 15—30 degrees C (59—86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date. To dispose of the methylphenidate patch after wearing it, fold in half and press firmly so that the sticky side sticks to itself. Dispose of in an trash container with a lid, away from the reach of children and pets. Wash your hands after handling the patch. Last Updated:08/09/2006 CLINICAL PHARMACOLOGY© GOLD STANDARD MULTIMEDIA INC, ALL RIGHTS RESERVED

Note: The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist, or other healthcare professional. It should not be construed to indicate that the use of the product is safe, appropriate, or effective for you. Consult your healthcare professional before taking the product.